NATIONAL CANCER INSTITUTE – In 2019, an estimated 606,880 people will die of cancer in the United States. Lung and bronchus cancer is responsible for the most deaths with 142,670 people expected to die from this disease. That is nearly three times the 51,020 deaths due to colorectal cancer, which is the second most common cause of cancer death. Pancreatic cancer is the third deadliest cancer, causing 45,750 deaths.